P-205 comparison of GnRH antagonist protocol versus progestin-primed protocol in high ovarian responders: a propensity score-matched study

Abstract Study question To compare the clinical outcomes and cost-efficiency between gonadotropin-releasing hormone (GnRH) antagonist progestin-primed ovarian stimulation (PPOS) protocol in high responders. Summary answer Comparing with PPOS protocol, GnRH was associated shorter time to live birth, higher OHSS rate less cost What is known already For responders prone develop hyperstimulation syndrome (OHSS), best option should be antagonist, as it has been shown significantly reduce incidence of OHSS. By applying using combination agonist trigger embryos freezing, can erased. a freeze-all strategy proved valid alternative conventional protocols. Recent studies showed that comparing lower cumulative birth (CLBR) general population, no data available design, size, duration This propensity score-matched retrospective cohort study. From Jan. 2016 2023, 5810 patients AMH > 3.67ng/ml undergoing IVF treatment or at Sixth Affiliated Hospital Sun Yat-sen University were screened. Participants/materials, setting, methods Two-to-one score matching performed caliper 0.2. After matching, 540 group 270 included. Generalized estimated equation regression applied evaluate impact independent variables on CLBR. Main results role chance No significant difference baseline characteristics found two groups. The (moderate severe) than (7% vs. 3%). pregnancy per transfer comparable excluding who didn't achieve but had surplus embryos, CLBR (67.4% 61.0%; Risk ratio = 1.106; 95% confidence interval [CI], 0.973-1.256, P 0.109), generalized analysis also selection average (TTLB) (11.45 months 12.13 months, < 0.05). Besides, about $4933, while $5465 group. Limitations, reasons for caution Although we recruited large sample size sophisticate statistical method, this study an intrinsic limitation, besides more (24.1% 19.8%). Further prospective RCTs are required confirm our findings. Wider implications findings infertile reserve, TTLB cost-effective, rate. Trial registration number Not Applicable